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Fiction and Fact about Treatment Duration

Chemotherapy. 2006 Feb 22;52(2):53-59

Fiction: "Early Lyme disease is readily treatable with a 2- to 3-week course of antibiotics."

Fact: This statement is misleading for several reasons. First, 'early Lyme disease' often goes undetected due to lack of awareness of a tick bite and absence of an EM rash [30] .

Second, recent studies have shown that tick saliva carries immunosuppressive substances that allow tickborne agents to invade tissues while paralyzing the local immune response [31, 32] .

Thus the Lyme disease spirochete may rapidly disseminate and become entrenched and resistant early in the disease (see below) [33-35] .

Third, coinfections may alter the course of 'early Lyme disease', and these coinfections may make the Lyme disease patient more difficult to treat (see below).
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