Or...Search This Site Home Symptoms Live Discussion Diagnosis Treatment World-wide Support Finder Library Research Lymelinks Contact Pets & Lyme DONATIONS Drug Info Medical Dictionary Board of Directors      Click on the graphic to vote for this site as a Starting Point Hot Site. -- No Warranties or Representations The data and information presented in this web site are presented in good faith and believed to be accurate. Any and all liability for the content or any omissions including any inaccuracies, errors, or misstatements in such data or information is expressly disclaimed. The web site is compiled for the sole purpose of informing community members of resources and information pertaining to Lyme Borreliosis Disease and its coinfections. The Canadian Lyme Disease Foundation, Directors and members are not liable for any direct or indirect damages or any damages whatsoever resulting from loss of use, data or profits, whether in an action of contract, negligence or other tortious action arising out of or in connection with the use or performance of information available from this website. Consult a qualified Lyme ( Borreliosis ) Disease literate doctor for medical advice if Lyme Disease is suspect. en français For Physicians Ticks Coinfections Prevention Our Stories Click Here to order our free Lyme Disease Flyer,    Here for our free Lyme Disease Poster ..documents may be copied (to distribute) but edit only for alignment. An in Vitro Study of the Activity of Telithromycin against Mobile and Cystic Forms of Borrelia afzelii. "The activity was unexpectedly high," http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Ab stract&list_uids=16501899&query_hl=13&itool=pubmed_docsum Infection. 2006 Feb;34(1):26-8. Brorson O, Brorson SH. Dept. of Microbiology, Vestfold Sentralsykehus, Tonsberg, Norway. In this study the new ketolide telithromycin was tested in vitro against motile and cystic forms of Borrelia afzelii, one of the species of Borrelia burgdorferi sensu lato. Acridine orange staining, dark field microscopy, and transmission electron microscopy were the techniques used to study the influence of telithromycin on the bacteria. The activity was unexpectedly high, 0.0003 microg/ml < MBC <./= 0.0006 microg/ml for the mobile forms after 7 days of incubation at 34 degrees C. MIC was < 0.00015 microg/ml. It is likely that the agent works bacterostatically and kills in a time-dependent and concentration-dependent way, by binding tightly to the ribosomes. The agent was not able to prevent cyst formation, and the cysts were not affected at an in vivo achievable concentration.Electron microscopy also supports the hypothesis of telithromycin being an effective agent against the mobile bacteria. TOP