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Acta Neurologica Scandinavica
Volume 112 Issue 5 Page 287 - November 2005
doi:10.1111/j.1600-0404.2005.00482.x

PCR in lyme neuroborreliosis: a prospective study

D. Pícha, L. Moravcová, E. dárský, V. Mareová, V. Hulínský

Pícha D, Moravcová L, dárský E, Mareová V, Hulínský V. PCR in lyme neuroborreliosis: a prospective study.

Acta Neurol Scand 2005: 112: 287292. © Blackwell Munksgaard 2005.

Objectives DNA proof is the only widely available direct diagnostic tool in Lyme borreliosis. Sensitive PCR detecting of spirochetal DNA was prepared and a prospective study in neuroborreliosis was performed.

Materials and methods 57 hospitalised patients with active neuroborreliosis and proved CSF antibodies synthesis were examined. Nested-PCR (utilizing three targets) was used for the detection of specific DNA in plasma, CSF and urine.

Results Before treatment 36 positive patients (63.1%) were found in all tested specimens in parallel, 28 patients (49.1%) were positive in urine, 20 in CSF (35.0%) and 16 in plasma 28.0%). Later only urine was tested and the following results were obtained: 17 positive patients (30.0%) immediately after treatment, 8 (14.0%) after 3 months and one patient persisted positivity after 6 months.

Conclusions The highest sensitivity of PCR was achieved in the acute period of neuroborreliosis - 63.1% in three body fluids comparing with CSF antibody synthesis.