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Lyme Disease symptoms vary from person to person. (lymes disease lyme's disease lime disease limes disease)
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Canlyme..."In speaking with one of the author's of this study it is their feeling that their findings lean more towards Chronic Lyme Disease being an autoimmune type disorder as opposed to active infection.
They need to do more research before any final conclusions can be drawn":
Could this be fallout or residue from the LYMErix debacle?
Journal of Neuroimmunology
Volume 159, Issues 1-2 , February 2005, Pages 192-195
Antibodies against OspA epitopes of Borrelia burgdorferi
cross-react with neural tissue
Armin Alaedini , and Norman Latov
1300 York Ave., Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, United States
Received 8 October 2004; accepted 8 October 2004. Available online 26 November 2004.
Abstract
Neurological sequela of chronic Lyme disease include encephalopathy, myelopathy and peripheral neuropathy. These have generally been attributed to either persistent infection or pathogen-induced autoimmunity. In this study, we investigated the presence of cross-reactive human neural epitopes that share amino acid sequences with Borrelia burgdorferi OspA protein. Sequence similarity analysis was carried out by searching known cDNA sequences from brain tissue. The cDNA database search yielded three sequences that were identical to sequences in OspA. Corresponding peptides were synthesized and antibodies were generated against them in rabbits.
Antibodies against two of the homologous OspA peptides were found to react with neurons in human brain, spinal cord and dorsal root ganglia by immunohistochemistry.
Keywords: Lyme disease; Nervous system; OspA; Autoimmunity; Cross-reactivity
Corresponding author. Tel.: +1 212 746 4944; fax: +1 212 746 5688
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