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Lyme Disease symptoms vary from person to person. (lymes disease lyme's disease lime disease limes disease)
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Metamorphosis of Borrelia burgdorferi organisms--RNA, lipid and protein composition in context with the spirochetes' shape.
Contrary to what the Infectious Disease Society of America (IDSA) has implied to the medical world, evidence mounts to support that viable Borrelia burgdorferi with the ability to reproduce can and do survive threat from antibiotics and the immune system.
[CanLyme note: This research adds more validity to the growing body of evidence that supports what patients have been trying to tell the medical community for over two decades, which is that they are still sick with active infection despite the short 21 to 60 day antibiotic regimen imposed by the IDSA in their guidelines, and that they improve substantially while on antibiotic therapy. A percentage of patients have stated over and over again that they only begin to get well, or are able to stay well with prolonged antibiotic therapy. Physicians in North Amnerica have withheld long term antibiotics from patients based upon the erroneous guidelines of the IDSA.
Here below the research shows that while under threat of antibiotics the bacteria's sphere forms show "reduced immune activity" which can account for why the patient is much less symptomatic while on antibiotics, allowing for a significant improvement in morbidity.
This finding could further support the evidence that there may be a great impact on the cost of government and non-govermental disability payments to individuals who can return to the workforce if given access to long term antibiotics. Furthermore, individuals who are refused long term antibiotics and who are left ill will be heavy users of the already financially stressed medical system]...
J Basic Microbiol. 2010 Dec;50 Suppl 1:S5-17
Al-Robaiy S, Dihazi H, Kacza J, Seeger J, Schiller J, Huster D, Knauer J, Straubinger RK.
Institute of Immunology, College of Veterinary Medicine, and Center for Biotechnology and Biomedicine, University of Leipzig, Germany
Abstract
Borrelia burgdorferi, the agent of Lyme borreliosis, has the ability to undergo morphological transformation from a motile spirochetal to non-motile spherical shape when it encounters unfavorable conditions. However, little information is available on the mechanism that enables the bacterium to change its shape and whether major components of the cells--nucleic acids, proteins, lipids--are possibly modified during the process. Deducing from investigations utilizing electron microscopy, it seems that shape alteration begins with membrane budding followed by folding of the protoplasmatic cylinder inside the outer surface membrane. Scanning electron microscopy confirmed that a deficiency in producing functioning periplasmic flagella did not hinder sphere formation. Further, it was shown that the spirochetes' and spheres' lipid compositions were indistinguishable. Neither phosphatidylcholine nor phosphatidylglycerol were altered by the structural transformation. In addition, no changes in differential protein expression were detected during this process. However, minimal degradation of RNA and a reduced antigen-antibody binding activity were observed with advanced age of the spheres. The results of our comparisons and the failure to generate mutants lacking the ability to convert to spheres suggest that the metamorphosis of B. burgdorferi results in a conditional reconstruction of the outer membrane. The spheres, which appear to be more resistant to unfavorable conditions and exhibit reduced immune reactivity when compared to spirochetes, might allow the B. burgdorferi to escape complete clearance and possibly ensure long-term survival in the host.
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