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Chronic Vasculitis and Polyneuropathy due to Infection with Bartonella henselae, lyme disease, lime disease, limes disease, lime's disease, juvenile arthritis in canada, JA
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BARTONELLA

"Dr. Edward Breitschwerdt, an infectious disease veterinarian and one of the world's leading researchers of bacteria called Bartonella, has for the first time documented evidence that the pathogen may have been passed between family members." Read More
Numbers of newly discovered species of Bartonella that are human pathogens are increasing rapidly.

Bartonella has been found in Ixodid ticks and as a co-infection in patients with Lyme Disease. It is also a stand alone infection in many. Bartonellosis can also be caused by insect bites, cat scratch (also called cat scratch fever), playing with rodents, and contact with dog saliva so as a result this, it is a much larger under-reported illness that we are only beginning to understand the long term consequences of if left untreated or not diagnosed early. See a poster presentation of a case study, 'Ataxia following an altercation... with a cat'

Symptoms of Bartonella are almost impossible to distinguish from Lyme, but may include a rash, lymphadenopathy, splenomegaly, hepatomegaly, headache, encephalopathy, somnolence, flu-like malaise, weight loss, sore throat, osteolysis, osteomyelitis, bacillary angiomatosis, and a papular or angiomatous rash. In acute cases, there can be hemolysis with anemia, high fever, weakened immune response, jaundice, abnormal liver enzymes, and myalgias. Endocarditis and myocarditis have been reported. More severe infections are associated with immune deficiency and possibly occurrence of opportunistic infections. As in Lyme Disease and Babesiosis, Bartonella may be transmitted to the fetus in the infected pregnant patient.

  • Bone marrow and skin granulomatosis in a patient with Bartonella infection
  • Cat-scratch disease: ocular manifestations and visual outcome.
  • Bartonella as a cause of mechanical prosthetic aortic root endocarditis.
  • New form of Bartonella in Peru.
  • In Emerging Infectious Disease
  • bartonella_emergence_2011.html
  • Bartonella, felines, humans
  • Case study in Virginia, variations of bartonella
  • Bartonella Rash Images
  • Bartonella overview
  • Do bartonella infections cause psychiatric disorders?
  • Bartonellosis as internal Bacillary Angiomatosis
  • Bartonella as vasculitis and polyneuropathy
  • See Canadian research info - Click Here
  • Usually rodent associated bartonella found in humans...CDC

  • Diagnostic tests include serology, blood and CSF PCR, and biopsy of skin lesions and lymph nodes.

    In the co-infected Lyme patient, eradication may be difficult. Many antibiotic agents have been reported to be effective, including cephalosporins, fluoroquinolones, erythromycins, gentamicin, rifampin and streptomycin. In practice, these patients seem to do best with a combination regimen that utilizes agents that can penetrate cells. Typical combinations include an erythromycin, plus a fluoroquinolone or rifampin.

    Treatment progress is most commonly assessed by PCR post treatment and serial titers.





    ...from Infectious diseases of the nervous system: pathogenesis and worldwide impact Paris, France. 10–13 September 2008

    BMC Proceedings 2008, 2(Suppl 1):P12

    The electronic version of this abstract is the complete one and can be found online at: http://www.biomedcentral.com/1753-6561/2/S1/P12

    Published: 23 September 2008

    © 2008 Defres et al; licensee BioMed Central Ltd.

    Poster presentation

    Cat scratch disease is caused by infection with Bartonella henselae of which cats serve as the natural reservoir. The disease is typically characterized by self-limiting regional lymphadenopathy.

    Although rare, < 2% of cases, a wide range of neurological manifestations have been described including encephalopathy, cerebellar ataxia, radiculitis and transverse myelitis.

    We present a 30 year old immunocompetent man who was admitted to the medical admission unit with a 4 day history of fever and headache. Examination findings were negative for any meningism and only revealed a temperature of 38.6 and an enlarged right epitrochlear lymph node. His 5th digit on his right hand was inflamed at the site of a previous cat scratch 8 weeks prior. He underwent excision biopsy of the lymph node and commenced azithromycin thereafter. Within 2 days his fever had completely settled, however, he developed left sensorineural hearing loss, opthalmoplegia and some nocturnal agitation. CT head at this point excluded any space occupying lesions including abcesses. The following day he was found to have an ataxic gait. Neurological findings showed unremarkable limbs with the exception of limb ataxia. Cranial nerve examination revealed limited abduction bilaterally with associated nystagmus in the contra-lateral eye. In addition there was a left facial weakness involving both the upper and lower face and left sided sensorineural hearing loss. Clinically there was a concern of a Bickerstaff's brainstem encephalitis secondary to the cat scratch disease. Other infections were excluded. His neurological conditions continued to deteriorate over the following 48 hours, becoming progressively encephalopathic and ataxic and he was given a course of intravenous immunoglobulin. His neurological problems gradually resolved over the next 7 days. Later serology and PCR from the lymph node confirmed infection with Bartonella species.

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