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No Warranties or Representations
The data and information presented in this web site are presented in good faith and believed to be accurate regarding Lyme disease (commonly misspelled lymes disease lyme's disease lime disease limes disease) and other related diseases. Any and all liability for the content or any omissions including any inaccuracies, errors, or misstatements in such data or information is expressly disclaimed. The web site is compiled for the sole purpose of informing community members of resources and information pertaining to Lyme Borreliosis Disease and its coinfections. Lyme disease symptoms may vary from person to person.
The Canadian Lyme Disease Foundation, Directors and members are not liable for any direct or indirect damages or any damages whatsoever resulting from loss of use, data or profits, whether in an action of contract, negligence or other tortious action arising out of or in connection with the use or performance of information available from this website.
Consult a qualified Lyme ( Borreliosis ) Disease literate doctor for medical advice if Lyme Disease is suspect.
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August 2005, 24:8 > Diagnostic Utility of Borrelia...
Diagnostic Utility of Borrelia burgdorferi Cerebrospinal Fluid
Polymerase Chain Reaction in Children with Lyme Meningitis.
Pediatric Infectious Disease Journal. 24(8):705-708, August 2005.
Avery, Robert A. DO, MA *[S]; Frank, Gary MD, MS *+; Eppes, Stephen
C. MD ++[S]
Abstract:
Background: Cerebrospinal fluid (CSF) laboratory tests are
frequently collected to help differentiate Lyme meningitis from other
causes of aseptic meningitis. Previous studies using Lyme CSF polymerase
chain reaction (PCR) have yielded varied results (sensitivity between 10
and 90%). No studies have specifically examined the diagnostic utility
of Lyme CSF-PCR in North American children with Lyme meningitis.
Methods: Retrospective chart review of children presenting to a
children's hospital in a Lyme-endemic region between October 1999 and
September 2004. Patients were included if they had both Lyme serology
and Lyme CSF-PCR performed during the same hospital encounter and had
documented meningitis. Patients were considered to have Lyme meningitis
if they had meningitis and met CDC criteria for Lyme disease. The Lyme
CSF-PCR assay amplified a Borrelia burgdorferi DNA flagellin gene sequence.
Results: Of 108 patients with meningitis who qualified for the
study, 20 patients met criteria for Lyme meningitis and 88 were
classified as aseptic meningitis. Positive Lyme CSF-PCR was found in 1
patient (1 of 20, 5%) with Lyme meningitis and one patient classified as
aseptic meningitis (1 of 88, 1%). Lyme CSF-PCR had a sensitivity of 5%
and a specificity of 99%. The only Lyme meningitis patient with positive
Lyme CSF-PCR had the highest CSF white blood cell count and CSF protein
values compared with the other Lyme meningitis patients.
Conclusions: This is the first study to evaluate Lyme CSF-PCR
exclusively in North American children. This commercially available
laboratory test is not generally helpful for identifying Lyme meningitis
because of its low sensitivity.
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