|
Home
|
|
Symptoms
|
|
Lyme Chat Group
|
|
Diagnosis
|
|
Treatment
|
|
World-wide Support Finder
|
|
Books/Video
|
|
RESEARCH
|
|
Lymelinks
|
|
Contact
|
|
Pets & Lyme
|
|
DONATIONS
|
|
Drug Info
|
|
Medical Dictionary
|
|
Board of Directors
|
Click on the graphic to vote for this
site as a Starting Point Hot Site.
|
|
|
No Warranties or Representations
Lyme Disease symptoms vary from person to person. (lymes disease lyme's disease lime disease limes disease)
The data and information presented in this web site are presented in good faith and believed to be accurate regarding Lyme disease (commonly misspelled lymes disease lyme's disease lime disease limes disease) and other related diseases. Any and all liability for the content or any omissions including any inaccuracies, errors, or misstatements in such data or information is expressly disclaimed. The web site is compiled for the sole purpose of informing community members of resources and information pertaining to Lyme Borreliosis Disease and its coinfections. Lyme disease symptoms may vary from person to person.
The Canadian Lyme Disease Foundation, Directors and members are not liable for any direct or indirect damages or any damages whatsoever resulting from loss of use, data or profits, whether in an action of contract, negligence or other tortious action arising out of or in connection with the use or performance of information available from this website.
Consult a qualified Lyme ( Borreliosis ) Disease literate doctor for medical advice if Lyme Disease is suspect to discuss your Lymes Disease Symptoms.
|
Clin Vaccine Immunol. 2007 Sep 19;
CVI Accepts, published online ahead of print on 19 September 2007
http://cvi.asm.org/cgi/content/abstract/CVI.00151-07v1
Serum Reactivity against Borrelia burgdorferi OspA in Rheumatoid
Arthritis.
Hsieh YF, Liu HW, Hsu TC, Wei JC, Shih CM, Krause PJ, Tsay GJ.
Institute of Immunology, Department of Medicine, Chung Shan Medical
University, Taichung, Taiwan, and Department of Parasitology and
Tropical Medicine, National Defense Medical Center, Taipei, Taiwan,
and Department of Pediatrics, University of Connecticut School of
Medicine, Farmington, Connecticut, USA.
* To whom correspondence should be addressed. Email: gjt@csmu.edu.tw
ABSTRACT
Lyme arthritis and rheumatoid arthritis share common clinical features
and synovial histology. It is unclear whether they also share a
similar pathogenesis.
Previous studies have shown that the severity and duration of Lyme
arthritis correlates directly with serum concentrations of antibody
against outer surface protein A (OspA) of the causative pathogen
Borrelia burgdorferi.
We tested the sera of 68 subjects with rheumatoid arthritis, 147
subjects with other autoimmune diseases, and 44 healthy subjects who
had never had Lyme disease, as well as that of 16 patients who had
Lyme disease, for reactivity against B. burgdorferi OspA protein.
The sera of about a quarter of the rheumatoid arthritis patients and a
tenth of the autoimmune disease and Lyme disease patients reacted
against OspA antigen. Of 50 rheumatoid arthritis patients who could be
evaluated for disease severity, a 28 joint count Disease Activity
Score of >2.6 was noted in 11 of 15 (73%) patients whose sera reacted
against OspA antigen and 13 of 35 (37%, p <0.05) whose sera was
non-reactive.
Serum reactivity against OspA antigen is associated with the
pathogenesis of rheumatoid arthritis.
TOP
|
| |
|
